In contrast, EHop-097 reduced actin cytoskeletal extensions without affecting cell polarity and was less effective at inhibition of EGF-induced actin ruffles in a lung adenocarcinoma cell line; demonstrating a different mechanism of action, as would be predicted by the structural and mechanistic differences of the compounds, as well as the different compliment of exchange factors that are active in lung cancer cells. This evidence concerns the gene EGF and lung carcinoma.