Since then, ATX was found overexpressed and implicated in many different cancers such as hepatocellular carcinoma (22), breast cancer (39), glioblastoma (40, 41), Hodgkin lymphoma (42), and non-small-cell lung cancer (43), with a growing evidence that it is directly involved in tumor progression, invasiveness, and dissemination through the production of LPA (2, 5, 44). Here, ENPP2 is linked to breast carcinoma.