Eventually, ATX levels are associated with cirrhosis grade whatever its cause may be, along with its complications (e.g., hepatic encephalopathy, esophageal varices, and portal hypertensive gastropathy), and it is an independent predictor of overall survival in this population, as demonstrated in a longitudinal cohort of 270 adult patients with liver cirrhosis followed until death, liver transplantation, or last contact (51). Here, ENPP2 is linked to cirrhosis of liver.