PTEN and hepatocellular carcinoma: Herein, in this study, we collected HCC patient samples from The Cancer Genome Atlas (TCGA) dataset, which has been used for identifying gene signature in children with stage III acute lymphoblastic leukemia [23] and analyzed the difference in PTEN gene expression in liver tumor tissue and adjacent tissue, copy number variation (CNV) and single-nucleotide variant (SNV) mutation, methylation, and some other factors.