Considering the importance of the PTEN gene and autophagy in HCC, we screened 5 genes (BFSP1, PPAT, EIF5B, ASF1A, and GNA14) associated with both the PTEN gene and autophagy by correlation analysis, univariate cox analysis, LASSO, and multivariate cox analysis. The gene discussed is ASF1A; the disease is hepatocellular carcinoma.