Similarly, a slightly positive correlation between the inflammation-based risk score and the concentration of IL-6 (p=0.564), IFN-γ(p=0.419), and IL-8(p=0.481) was found; while the degree of periodontal disease presented a slightly anti-correlation with the levels of IL-6 (p=0.369) and a positive correlation with the other cytokines (Supplementary Table 1). Here, CXCL8 is linked to periodontal disorder.