NFKB1 and metabolic dysfunction-associated steatohepatitis: TLR4 is a natural receptor of LPS and LPS-induced activation of TLR4 leads to NF-KB nuclear translocation, promotes the release of proinflammatory factors such as IL-6 and TNF-α, and induces the progression from simple fatty liver disease to NASH (Heida et al., 2021).