On the basis of these studies, we hypothesize that LoVo colorectal cancer cell line develops resistance to chemotherapeutic drugs by activating the hippo signaling pathway and activates LATS2, and YAP by phosphorylation and PD treatment in the parental and resistance LoVo cells could effectively modulate the hippo signaling pathway by inhibiting the phosphorylation of LATS2, and YAP. This evidence concerns the gene LATS2 and colorectal cancer.