Local recurrence after surgical resection was significantly associated with various factors, including age (P = 0.027), chemotherapy or radiotherapy for primary cancer prior to BM (P = 0.028), BM size (P = 0.039), adjuvant radiotherapy (RT; P < 0.001), PDGFR-β expression (P = 0.003), and α-SMA expression (P = 0.011). The gene discussed is ACTA1; the disease is cancer.