In the KEGG enrichment analysis, the 14 upregulated-hypomethylated genes were associated with Wnt signaling pathway, basal cell carcinoma, melanogenesis, signaling pathways regulating pluripotency of stem cells, breast cancer, gastric cancer, mTOR signaling pathway, Cushing syndrome, Hippo signaling pathway, and hepatocellular carcinoma (Figure 4G). Here, MTOR is linked to Cushing syndrome due to macronodular adrenal hyperplasia.