Later studies found that Erianin can inhibit tumor cell cycle progression and induce tumor death by inhibiting BCL2 apoptosis regulator (Bcl-2) and extracellular regulated kinase (ERK)1/2 and promoting BCL2 associated X, apoptosis regulator (Bax) and caspase-3 expression 9-11. This evidence concerns the gene CASP3 and neoplasm.