Bioinformatic analysis of 522 tumor tissues from patients with clear cell renal cell carcinoma and 99 tissue samples from non-tumor diseases in the online database GEPIA (http://gepia.cancer-pku.cn/) showed that the transcription copy numbers of FTO and P53 in tumor tissues were significantly higher than those in normal tissues (Figure 5A), while the transcription copy number of ALOX12 in tumor tissues was slightly lower than that in normal tissues (Figure 5A). This evidence concerns the gene TP53 and clear cell renal carcinoma.