In a previous study, we found that the compound fisetin suppressed Tet methylcytosine dioxygenase 1 (TET1) expression and reduced the 5hmC modification in specific loci in the promoters of CCNY (encoding cyclin Y)/CDK16 (encoding cyclin dependent kinase 16) in HuRSCs, which inhibited the transcription of these genes, causing cell cycle arrest and ultimately inhibiting renal cancer stem cell activity 4. This evidence concerns the gene CCNY and renal carcinoma.