CD8A and leukoplakia: When considering immune cell types in the DME, CD8+ T cells, and cytotoxic T cells are increased among proliferative leukoplakia samples when compared with localized leukoplakia, while quantitative and spatial techniques clarify this occurs across all regions of the stroma and dysplastic tissue with the highest mean density of PD-1+ CD8+ T cells and Tregs homing to the DSI.