The proportions of FCRL4+ B cells and memory B cells were higher in the EBV DNA Sero+ samples, whereas that of the proliferating B cells and germinal center B cells were higher in the EBV DNA Sero- samples, indicating a strong immunoregulatory potential in EBV DNA Sero+ NPC. This evidence concerns the gene FCRL4 and nasopharyngeal carcinoma.