On the other hand, IFN response promotes immunosuppressive effects, including mediating the inactivation of B cells to block antibody protective mechanisms (46, 47), inducing the expression of inhibitors and co-simulators to mediate tumor-promoting effects (45, 48, 49), and downregulating the expression of MHC class I molecules to evade immune surveillance (50). Here, IFNA1 is linked to neoplasm.