Differential gene expression analysis showed that CDKN2A, ATF3, CXCL10, and interferon (IFN) stimulated genes (IFI6, IFIT3, IFI44L, IFITM1, etc.)were significantly upregulated in EBV DNA Sero+ NPC cells (Figure S2), suggesting more active EBV viral activity. The gene discussed is ATF3; the disease is nasopharyngeal carcinoma.