CD40LG and melanoma: In clinical practice, monocyte-derived DCs (moDCs) electroporated with mRNA encoding TAAs in conjunction with TriMix mRNA, a mix of three mRNA molecules encoding CD40 ligand (CD40L), CD70, and a constitutively active variant of TLR4 (caTLR4), has shown an unprecedented capacity to increase the life expectancy of stage III/IV melanoma patients.