CXCL1 and CXCL8 induce neutrophil chemotaxis in vitro, which is also inhibited by the blockade of CXCR1/CXCR2 and DF 2162, the later inhibiting neutrophil recruitment in zymosan-induced arthritis in mice and AIA in rats (166, 167). This evidence concerns the gene CXCR2 and arthritic joint disease.