CCR4, CCR6, CCR7, CCR9, CXCR5, and CXCR6 deficiency ameliorated arthritis in CIA mice by suppressing the migration of Th17 cells (CCR4), DC (CCR7), and CD11b+ splenocytes (CCR9) (82, 84, 160, 190, 196, 197). The gene discussed is CCR6; the disease is arthritic joint disease.