CXCR5 and arthritic joint disease: CXCR5 KO mice are resistant to CIA development; B cell-specific CXCR5 deficiency leads to mild arthritis with impaired germinal center (GC) response and antibody production, whereas T cell-specific CXCR5 deficiency promotes resistance to arthritis development by impaired GC response, antibody production, and inflammatory cytokine response (160).