Previous studies found that there were not only nuclear and cytoplasmic antigen antibodies in the serum of SLE patients, but also some common antibodies of other autoimmune diseases, such as anti-phospholipid antibodies, anti-Ro antibodies, anti-La antibodies, etc. (27) The GWAS studies found that some SNPs associated with SLE were also associated with multiple autoimmune diseases (28). This evidence concerns the gene CALR and autoimmune disease.