High scores were also observed for the interactions of S100A8/A9 with ITGB2, which have been linked to the induction of neutrophil chemotaxis and adhesion during inflammatory processes and immune response (37, 38), as well as the transmigration of leucocytes including T-cells in the context of GvHD (39, 40). The gene discussed is IGKV1D-22; the disease is graft versus host disease.