Based on LASSO logistic regression and SVM-RFE algorithms, we identified GNG8, MYH1, CHRNA3, DPEP1, PRSS35, CKMT1B, CNKSR1, C14orf180, POU3F1, SAG, POU2AF1, IGFBPL1, CDCA7, ZNF492, ZDHHC22, and SFRP2 as DEGs of liver cancer immunotherapy. Here, MYH1 is linked to liver cancer.