Based on LASSO logistic regression and SVM-RFE algorithms, we identified GNG8, MYH1, CHRNA3, DPEP1, PRSS35, CKMT1B, CNKSR1, C14orf180, POU3F1, SAG, POU2AF1, IGFBPL1, CDCA7, ZNF492, ZDHHC22, and SFRP2 as DEGs of liver cancer immunotherapy. The gene discussed is IGFBPL1; the disease is liver cancer.