Pharmacological NR1D1 activation represses pro-inflammatory cytokine secretion and promotes IL-10 in primary rat microglia (54), in murine models of colitis (55), in the lungs of murine models of inhaled LPS (56), in the livers of murine models of fulminant hepatitis, and in murine and human macrophages (57). The gene discussed is NR1D1; the disease is Fulminant hepatitis.