In the Hallmark gene sets (Figure 7C), the results indicated that relevant pathways with high expression level in the high-risk group were IL6-JAK-STAT3 signaling, allograft rejection, interferon gamma response, interferon alpha response, TNFα signaling, coagulation, complement, apoptosis, hypoxia, angiogenesis, epithelial-mesenchymal transition (EMT), which were mainly involved in immune and inflammatory response and tumor progression. The gene discussed is TNF; the disease is neoplasm.