By comparing the top 20 genes with highest frequency of somatic mutations in low- (n=441) and high-risk (n=203) group, we found that higher frequency of IDH, ATRX, and CIC mutations in gliomas with low LRS risk (Figure 6B), while mutations of EGFR, PTEN, and NF1 were more frequent in the high-risk group (Figure 6C). This evidence concerns the gene IDH1 and central nervous system cancer.