Subsequently, according to the CytoHubba plug-in of Cytoscape, we screened nine candidate hub genes, including CXCL8, CCL2, CD44, ICAM1, IL1A, CXCR2, PTPRC, ITGAX, and CSF3, which were all elevated in both CKD and UC patients. Here, CD44 is linked to chronic kidney disease.