HGF and colitis: Similarly, in the treatment of experimental murine colitis, preconditioning cAD-MSCs with the mixture of IFNγ/TNFα (20 ng/mL, 24 h) upregulated the expression of immunosuppressive proteins such as hepatocyte growth factor (HGF) and transforming growth factor beta (TGF-β), thus dominating the polarization of macrophages (28).