IL12A and autoimmune uveitis: For example, one study showed that IL-12α suppresses lymphocyte proliferation and ameliorates autoimmune uveitis in mice by antagonizing pathogenic Th17 responses through induction of IL-10 and IL-35-expressing regulatory B cells (27), while other studies demonstrated that inhibition of IL-12α by genetic deletion significantly attenuated macrophage polarization, T cell derived interferon-γ (IFN-γ) production, and cardiac injury repair after myocardial infarction (28).