Based on the autoregressive model, the path from baseline CRP to depression in 2013 (ßstd = −0.01, p = 0.81) and the path from baseline CRP to depression in 2015 (ßstd = 0.02, p = 0.47) were not significant in the CRP main-effect model, suggesting that baseline CRP could not prospectively predict depression at further time points after controlling all synchronous relations and all stability coefficients. The gene discussed is CRP; the disease is major depressive disorder.