Our results lend partial support to studies on middle-aged and older adults that found no association between elevated CRP and higher odds of depression before and after adjusting for demographic, socio-economic, lifestyle, and prior medical history variables (Pan et al., 2008; Stewart et al., 2008, 2009; Song et al., 2015; de Menezes et al., 2017). This evidence concerns the gene CRP and depressive symptom measurement.