Based on the autoregressive model, the paths from baseline CRP to depression in 2013 (ßstd = −0.01, p = 0.80), from baseline CRP to depression in 2015 (ßstd = 0.02, p = 0.47) were not significant in the CRP main-effect model, from baseline depression to CRP in 2015 (ßstd = −0.02, p = 0.40), and from depression in 2013 to CRP in 2015 (ßstd = 0.03, p = 0.31) were not significant in the CRP-depression reciprocal model, suggesting that CRP and depression could not prospectively predict each other at further time points after controlling all synchronous relations and all stability coefficients. This evidence concerns the gene CRP and major depressive disorder.