Based on the autoregressive model, the path from baseline depression to CRP in 2015 (ßstd = −0.02, p = 0.41) and the path from depression in 2013 to CRP in 2015 (ßstd = 0.03, p = 0.30) were not significant in the depression main-effect model, suggesting that depression could not prospectively predict CRP at further time points after controlling all synchronous relations and all stability coefficients. The gene discussed is CRP; the disease is major depressive disorder.