Based on the autoregressive model, the path from baseline depression to CRP in 2015 (ßstd = −0.02, p = 0.41) and the path from depression in 2013 to CRP in 2015 (ßstd = 0.03, p = 0.30) were not significant in the depression main-effect model, suggesting that depression could not prospectively predict CRP at further time points after controlling all synchronous relations and all stability coefficients. This evidence concerns the gene CRP and depressive disorder.