Cross-lagged regression path analyses revealed that the paths from baseline CRP to depression in 2013 (ßstd = −0.01, p = 0.80), from baseline CRP to depression in 2015 (ßstd = 0.02, p = 0.47), from baseline depression to CRP in 2015 (ßstd = −0.02, p = 0.40), and from depression at 2013 to CRP in 2015 (ßstd = 0.03, p = 0.31) were not statistically significant. This evidence concerns the gene CRP and depressive symptom measurement.