The high-sensitivity test for CRP, called low-reactive protein (LRP, L-CRP, or hs-CRP), more accurately measures very low levels of CRP, and static sampling of CRP has been widely used in clinical studies to predict diseases, such as cancer and depression (Coventry et al., 2009; Felger et al., 2020; Nehring et al., 2022). Here, CRP is linked to major depressive disorder.