Consistent with the results of previous studies in some Asian regions, such as Islamabad, there was a lack of association between CRP and depression influenced by racial/ethnic, genetic, and environmental factors, and population-based assessments of associations between physiological processes or social integration should consider these variables (Chapman and Santos-Lozada, 2020; Zavos et al., 2022). The gene discussed is CRP; the disease is major depressive disorder.