IDH1 and central nervous system cancer: To validate the expression and prediction value of NDUFB2 in the Chinese Glioma Genome Atlas (CGGA), we first explored the expression of NDUFB2 in different grades of glioma and we found that it was increased with the higher degree of glioma (Supp Fig 1A); meanwhile, the expression of NDUFB2 is much lower in the IDH-1 mutant type compared to IDH-1 wild-type groups (Supp Fig 1B).