All the 10 mutations identified in the screen were at ERBB4 residues that have been reported to harbor mutations in patient-derived cancer samples listed in public cancer registries (COSMIC, cBioPortal, and AACR GENIE) with an identical missense mutation (same residue substituted with same residue) in 5 of the 10 (Supplementary Fig. S4). This evidence concerns the gene ERBB4 and cancer.