Several studies showed that S100A11 is overexpressed in various malignant tumors, such as lung cancer 17, gastric cancer 18, cervical squamous cell carcinoma 19, breast cancer 20, glioblastoma 14, etc. However, it plays a tumor-suppressive role in bladder cancer 21, indicating that S100A11 has a double effect on regulation of cancers. The gene discussed is S100A11; the disease is urinary bladder carcinoma.