In a comparison of RNA-seq gene expression data from primary ovarian cancer and PDX samples, 43% of downregulated genes in PDX samples were either known macrophage markers (e.g.,CD68, CD163), involved in macrophage polarization (e.g., MALAT1, NEAT1, IL10RA) or responsible for immune infiltration (e.g., THBS1, THBS2, ITGA5, and collagens; Fig. 1A; Supplementary Table S3). This evidence concerns the gene THBS2 and ovarian cancer.