High estrogen receptor signaling separated hormone receptor (HR)-driven BRCAs from all other tumors (Fig. 1D), while high inflammation characterized tumors with known immunologic involvement, including SKCM, Epstein–Barr virus positive STES, immunoreactive OV, THYM, and acute myeloid leukemia (LAML; Fig. 1F). The gene discussed is ESR1; the disease is acute myeloid leukemia.