In MDS, 5q deletion causes haploinsufficiency of several genes (52), including RPS14, CSNK1A1, APC, DDX41, and miR-145/miR-146a, leading to deregulated p53-mediated apoptosis, WNT/β-catenin, and inflammatory signaling. The gene discussed is CSNK1A1; the disease is myelodysplastic syndrome.