Among them, we highlight the synergistic relationship of TP53 and aneuploidy which act in concert to execute an aggressive transcriptional program of high proliferative and high glycolysis expression, especially in squamous cell carcinomas and the basal-like and basal/squamous-like subtypes of breast cancer adenocarcinoma (BRCA) and bladder urothelial carcinoma (BLCA), respectively. Here, TP53 is linked to bladder transitional cell carcinoma.