One high-proliferative cluster characterized by high EMT signature consisted of mesenchymal tumors, including the sarcomas, mesenchymal subtype of OV, and isocitrate dehydrogenase (IDH) wild-type glioblastoma multiforme, of which more than one-third were previously reported to show a mesenchymal phenotype (ref. 46; Fig. 1E). Here, IDH3A is linked to sarcoma.