TP53 and adenocarcinoma: reported that adenocarcinomas of the ileocecum and cecum were detected in 70% of TCR‐β (−/−)/p53(−/−) mice in the conventionally fed group but not in the germ‐free group, suggesting that intestinal microbiomes play a major role in the development of adenocarcinoma of the colon in this animal model.103