Streptococcus gastrop (Peptostreptococcus anaerobius) interacts with TLR2 and TLR4 in colon cells to regulate a variety of immune cell types including myeloid‐derived suppressor cells (MDSCs), tumor‐associated macrophages (TAMs), and granulocyte tumor‐related neutrophils, thus promoting colon carcinogenesis.203. The gene discussed is TLR4; the disease is neoplasm.