To determine a potential ADAM17 dependence of IR-induced migration, the transwell migration assay was performed with tumor cells, that were stably transfected with doxycycline-inducible ADAM17-directed shRNAs (shADAM17_2 and shADAM17_3; Supplementary Fig. S1C and S1D). The gene discussed is ADAM17; the disease is neoplasm.