ADAM17 and neoplasm: To assess the role of the IR-induced sheddase activity of tumor cell–expressed ADAM17 for HUVEC migration, the transwell migration assay was performed with nonirradiated and irradiated A549 and NCI-H358 cells, that were preincubated with the ADAM17-directed inhibitory antibody MEDI3622 (Supplementary Fig. S1F).