Knockdown of ADAM17 in the attracting lung adenocarcinoma tumor cells A549 (A549_shADAM17_2 and _3) and NCI-H358 (H358_shADAM17_2 and _3) minimally reduced basal migration of HUVECs, but strongly abrogated migration of HUVECs toward irradiated ADAM17-knockdown lung adenocarcinoma cells in comparison with endothelial cells migrating toward ADAM17-proficient tumor cells (A549_shNT and H358_shNT; Fig. 1A). Here, ADAM17 is linked to neoplasm.