The development of NAFLD in humans strongly correlates with the dysregulation of transcriptional regulators that affect lipid metabolism (CAR, ChREBP, C/EBPα, FXR, LXR, PPARα/γ/δ, SREBP1c, STAT5), inflammation (c-Jun, C/EBPβ, IRF1/3, NF-κB, RELA, SHP, STAT1/3), metabolic stress (ATF4/6, CYP2E1, eIF2α, IRE1α, Nrf2, Xbp1), and fibrosis (AEBP1, RUNX2, Smad/TGFβ, YAP) (Steensels et al., 2020). This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.