CHAF1B is a subunit of the chromatin assembly factor-1 (CAF-1), which plays a role in DNA replication and repair; it is a proliferation marker in breast cancer and has been associated with histologic grade in breast and other cancers; its knockdown inhibits tumor growth and migration in a model of hepatocellular carcinoma (89, 90). The gene discussed is CHAF1B; the disease is breast cancer.