CASC8 and breast cancer: Furthermore, MYC is the most altered gene among patients harboring alterations in at least 1 of the 7 downregulated genes, followed by the lncRNAs CASC8, POU5F1B, CCAT1, PVT1, PCAT1, and PRNCR1, which not only belong the 8q24 gene locus (that contains MYC), commonly amplified in breast cancer, but also have been associated with promoting MYC-induced tumorigenesis (68, 69).