DEPDC1B is upregulated in lung cancer, shows a negative correlation with patient survival and has been linked to a metastasis-related malignant phenotype (96); it has also been described as tumor- or metastasis-promoting in various other cancer types, such as glioblastoma, bladder, prostate, and pancreatic cancer (97–100). Here, DEPDC1B is linked to familial pancreatic carcinoma.