In this article, we measure the effects of pyrvinium pamoate (PP; a Wnt signaling antagonist; ref. 11) combined with either a proapoptotic drug (ABT263; ref. 12) or an anti-inflammatory drug (sulindac; refs. 13, 14) on colon adenoma formation in two independent Apc-mutant dextran sulphate sodium (DSS)-treated mouse models (10, 15). This evidence concerns the gene APC and colon adenoma.