After the combination of basal insulin, the percentage of glucose within the target range (4.4-10.0 mmol/L) increased (34.4% vs 46.7%, P < 0.001), and that of hyperglycemic events decreased with a slight increase in level 1 hypoglycemia (3.0-3.8 mmol/L) (0.5% vs 1.5%, P < 0.001) but no change in level 2 hypoglycemia (< 3.0mmol/L) (Figure 1A). The gene discussed is INS; the disease is Hypoglycemia.