Functional, pathway, and gene network analyses of genes within the KIAA1549:BRAF fusion region were performed using several bioinformatics tools, including DAVID (13) and IPA (QIAGEN Inc.)that indicated enrichment in cancer, cell cycle, cellular development, and nervous system development and function, and significant alterations in retinoic acid mediated apoptosis signaling, MAPK and death receptor signaling pathways (all p values < 0.01) (Figures 2A, B). This evidence concerns the gene KIAA1549 and cancer.