The analysis indicated alterations in retinoic acid mediated apoptosis signaling, MAPK and death receptor signaling pathways and hub genes, including BRAF, LUC7L2, MKRN1, TP53, HNF4A, RICTOR, POU5F, HIPK2, and SOX4 that may have potentially important role in tumorigenesis and cancer progression (2, 16, 22–25). This evidence concerns the gene MKRN1 and cancer.