In an intracardiac xenograft model that rapidly develops distant metastasis to bone and visceral organs through the bloodstream, overexpression of MAOA in the bone-tropic PC-3 cells promoted a higher incidence of metastasis and greater skeletal tumor burden, with more circulating tumor cells detected in peripheral blood at the endpoint, suggesting the heightened potential of metastatic seeding for further dissemination. This evidence concerns the gene MAOA and neoplasm.