PTEN and pachyonychia congenita: Overexpression of MAOA in PC-3 cells accelerated cancer cell proliferation, migration and invasion and tumor formation and growth, while genetic knockdown or pharmacological inhibition of MAOA reduced these aggressive behaviors in multiple human (LNCaP, C4-2 and ARCaPM) and mouse (MPC3 bearing a double knockout of Pten and Tp53) PC cell lines in vitro and in vivo (16).