The activation of dendritic cells releases a large amount of activated cytokines (including IL-1, IL-6, and IL-12) (41), which increase the number of transcriptional factor Foxp3 regulatory T cells (Foxp3+ Tregs) (49), and induce the differentiation of CD4+ T cells into Th1 cells (50), all of which lead to immunosuppression, and allow tumor cells to escape immune surveillance that promotes tumor progression. This evidence concerns the gene CD4 and neoplasm.