FOXP3 and neoplasm: The activation of dendritic cells releases a large amount of activated cytokines (including IL-1, IL-6, and IL-12) (41), which increase the number of transcriptional factor Foxp3 regulatory T cells (Foxp3+ Tregs) (49), and induce the differentiation of CD4+ T cells into Th1 cells (50), all of which lead to immunosuppression, and allow tumor cells to escape immune surveillance that promotes tumor progression.