SF3B4 and hepatocellular carcinoma: identified KPNA2 as a potential diagnostic and prognostic biomarker for HCC, which may affect HCC cell proliferation and migration by regulating cell cycle and DNA replication (54). Splicing factor 3b subunit 4 (SF3B4) has been revealed to be associated with the diagnosis and prognosis of HCC (55, 56). Liu et al.