It was found that CYP2C9, PON1 and CFHR3 were low expressed and MARCKSL1, SPP1, BSG, CCT3, LAGE3, KPNA2, SF3B4, GTPBP4 were over expressed in human hepatoma cells compared with normal human hepatocyte cells (Unpaired t-test, p<0.01) (Figure 7A). This evidence concerns the gene SF3B4 and hepatocellular carcinoma.