CYP2C9 and hepatocellular carcinoma: Figure 7B shows the results of the protein expression levels of CYP2C9 and PON1 were down regulated in HepG2 and HCC-LM3 compared to MIHA. At the same time, CPTAC database analysis results showed that the protein expression of PON1, CFHR3 and CYP2C9 were low expressed in tumor tissues compared with paracancer normal tissue, while other genes were over expressed (Figure 7C).