SPP1 and hepatocellular carcinoma: Based on the initial trend of differentially up- and down-regulated genes (Supplementary Table S4), To further investigate the gene expression characteristics of 11 prognosis-related differentially expressed genes (MARCKSL1, SPP1, BSG, CCT3, LAGE3, KPNA2, SF3B4, GTPBP4, PON1, CFHR3 and CYP2C9) in the high-risk and low-risk groups of HCC patients, we performed a correlation analysis between gene expression levels and risk scores.