BSG and hepatocellular carcinoma: The potential diagnostic role of BSG in differentiating HCC specimens from non-tumor specimens was demonstrated by analysis of multiple cohorts. BSG mRNA expression levels were significantly upregulated in both HCC specimens and HCC cell lines, and significantly shorter Overall Survival (OS) (P = 0.0014) and Disease Free Survival (DFS) (P = 0.0097) were observed in patients with high BSG expression relative to those with low BSG expression.