We found that breast cancer tissues with medium or high protein staining of UBE2S and UBE2C had negative or weak staining of Numb protein (Figure 3B, Cases 1–3>), whereas the lower protein levels of UBE2S and UBE2C displayed strong staining of Numb protein (Figure 3B, Case 4). The gene discussed is UBE2C; the disease is breast carcinoma.