To further clarify the negative correlation between UBE2S/UBE2C and Numb in breast cancer prognosis, we compared the OS and RFS in breast cancer patients divided into three groups: one with higher UBE2S or UBE2C and lower Numb expression (UBE2S or UBE2C high + Numb low), one with lower UBE2S or UBE2C and higher Numb expression (UBE2S or UBE2C low + Numb high), and the rest were categorized into the third group. This evidence concerns the gene UBE2C and breast cancer.