CD8A and lymphopenia: As an example, radiation-induced lymphopenia has been clearly linked with poorer survival outcomes in cancer patients, including NSCLC (Grossman et al., 2015; Venkatesulu et al., 2018; Jin et al., 2017; Ladbury et al., 2019; Tang et al., 2014) (25–29).Lining Li et alfindings ‘s supported the notion that CD8 T cells are reliable indicators for gauging patient response and survival after ICI (30).