In contrast to the findings of earlier studies, which demonstrated that patients with advanced stages of cancer are more likely to have high levels of CD3 and CD8 expression, this group of cases’ differences between the high and low expression groups of CD3 and CD8, respectively, in tumor stage were not statistically significant (P > 0.05) (34).Because there were fewer advanced cases in this research, early-stage cases were more common. The gene discussed is CD8A; the disease is cancer.