In a human in vitro stroke model, phoenixin-14 was shown to protect brain endothelial cells against oxygen-glucose deprivation/reoxygenation (OGD/R) injury through an attenuation of ROS and NADPH-Oxidase-1 (NOX1), while inhibiting high-mobility-group-box-1 (HMGB1) expression and simultaneously enhancing the protective molecule NO (Zhang and Li, 2020). Here, HMGB1 is linked to stroke disorder.