Increased levels of CD209 (IVW OR: 1.04; 95% CI: 1.02 to 1.06; p = 6.67 × 10−6) and USP25 (IVW OR: 1.06; 95% CI: 1.03–1.08; p = 7.83 × 10−6) were associated with increased risk of HF (Figure 3; Supplementary Figures S2, S3), with 22 SNPs explaining 48.0% variance (F statistic = 137.6) of CD209 and 17 SNPs explaining 24.0% variance (F statistic = 66.9) of USP25 (Supplementary Tables S3, S4). The gene discussed is USP25; the disease is hydrops fetalis.