In addition, CARD9 deficiency partially, but significantly, reversed the reduction in mechanical function in ischemic limbs of mice exposed to PM at days 14 and 21 (for swimming time: WT-PM vs. CARD9-PM: 116 mins vs. 139 mins at day 21, WT-PM vs. CARD9-PM: 148 mins vs. 177 mins at day 21; for limb ischemia recovery index: WT-PM vs. CARD9-PM: 2.6 vs. 1.7 at day 14, and 1.9 vs. 1.1 at day 21; *p < 0.05, Figures 5B, C). This evidence concerns the gene CARD9 and limb ischemia.