BECN1 and amyotrophic lateral sclerosis: Another ALS-associated mutation, the TAR DNA binding protein 43 mutation (TDP-43A315 T), was found to increase ER stress markers including CHOP, GRP78, and eIF2α, as well as autophagy markers such as Beclin-1 and LC3-PE (Medchalmi et al. 2021).