Downregulation of the IRE1α-XBP1 axis in Huntington’s disease and amyotrophic lateral sclerosis induces autophagy by upregulating the forkhead box (FOXO), which is known to elevate key autophagy-related genes such as ATG12, BECN1, BNIP3, GABARAPL1, and LC3, and promote pathological conditions (Salih and Brunet 2008; Vidal et al. 2012). The gene discussed is BECN1; the disease is amyotrophic lateral sclerosis.