Considering the fact that oxidative stress is a complex process involving different genes, in the present study, we proposed an oxidative stress-related gene signature composed of ACOX1, CPT2, NAT2, NRG1, PPARGC1A, CDKN2A, CRYAB, NGFR, and UCN to predict CRC patients’ clinical outcomes with the LASSO approach. The gene discussed is CDKN2A; the disease is colorectal carcinoma.