Considering the fact that oxidative stress is a complex process involving different genes, in the present study, we proposed an oxidative stress-related gene signature composed of ACOX1, CPT2, NAT2, NRG1, PPARGC1A, CDKN2A, CRYAB, NGFR, and UCN to predict CRC patients’ clinical outcomes with the LASSO approach. This evidence concerns the gene PPARGC1A and colorectal carcinoma.