Our experimental studies demonstrated that CDKN2A and UCN were up-regulated and ACOX1, CPT2, NAT2, NRG1, PPARGC1A, CRYAB, and NGFR were down-regulated in CRC cells (SW-480 and HCT-116) compared with human colorectal mucosal cells (FHC). This evidence concerns the gene CRYAB and colorectal carcinoma.