AKT1 and atherosclerosis: Furthermore, KEGG analysis revealed that HQGZ could affect multiple pathways, including pathways related to cancer, lipid and atherosclerosis, chemical carcinogenesis-receptor activation, IL-17 signaling pathway, PI3K-Akt signaling pathway, chemical carcinogenesis-reactive oxygen species, MAPK signaling pathway, neuroactive ligand-receptor interaction, alcoholic liver disease, and pathways of neurodegeneration-multiple diseases (Supplementary Table 3 and Figure 2(d)).