In particular, the following pathways were more affected22: Receptor‐mediated mitophagy (ATG5, ATG12, LC3A, and LC3B), PINK1‐PRKN Mediated Mitophagy (ATG12, P62, LC3A, LC3B, and ATG5) and the super pathway Macroautophagy (ATG12, ATG7, Rheb, ATG4A, ATG13, Beclin, P62, GABARAP, LC3B, ATG5, ATG10, LC3A, ATG3, and ATG4B) that displayed a trend of 22.0%, 21.6%, and 17.5% reduction in IBM fibroblasts. The gene discussed is ATG12; the disease is inclusion body myositis.