Folliculin has also been found to be an important binding partner and uncompetitive inhibitor of lactate dehydrogenase A (LDHA), and thus its absence leads to aerobic glycolysis otherwise known as the Warburg effect (Figure 3b).6–11 Although the exact mechanisms have yet to be elucidated, interruptions of these functions implicate dysregulation of folliculin functioning in the tumorigenesis of BHD. Here, LDHA is linked to Birt-Hogg-Dube syndrome.