This leads to deregulation of the Wnt/APC/β-catenin pathway and increased cell proliferation.21 While there has been no definitive connection made between the Wnt/APC/β-catenin pathway and the FLCN, APC mutations have also been proven to promote mTORC1 activation and result in the development of colon polyps. The gene discussed is FLCN; the disease is colon inflammatory polyp.