This leads to deregulation of the Wnt/APC/β-catenin pathway and increased cell proliferation.21 While there has been no definitive connection made between the Wnt/APC/β-catenin pathway and the FLCN, APC mutations have also been proven to promote mTORC1 activation and result in the development of colon polyps. This evidence concerns the gene APC and intestinal disorder.