The role of hsa-miR-503 in pathomechanism of diabetes complications depends on mitochondrial activity (DHFR), cell cycle control (CCNE2), cell protection (SOD2), podocyte migration (ANLN), inflammatory process (IL10, EFE2, VEGFA) and fibrosis (COL1A1), showing its contribution to CKD development. The gene discussed is CCNE2; the disease is diabetes mellitus.