The role of hsa-miR-503 in pathomechanism of diabetes complications depends on mitochondrial activity (DHFR), cell cycle control (CCNE2), cell protection (SOD2), podocyte migration (ANLN), inflammatory process (IL10, EFE2, VEGFA) and fibrosis (COL1A1), showing its contribution to CKD development. This evidence concerns the gene VEGFA and diabetes mellitus.