Expression of LAG-3 can be found on cells in the tumor microenvironment (TME) of various solid tumors, including non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinomas (HNSCC), and is commonly associated with a more aggressive tumor type and poor prognosis [6, 7]. The gene discussed is LAG3; the disease is head and neck squamous cell carcinoma.