LAG3 and neoplasm: Immunohistochemical staining of biopsied lesions confirmed low percentages of LAG-3 positive immune cells per tumor area for patients 6 and 9 (≤ 1% and 5%, respectively), as compared to patients 1, 2, and 10 (10%, 5%, 30%, respectively), supporting the notion that low mean tumor uptake of [89Zr]Zr-BI 754111 corresponds to low abundancy of (LAG-3+) immune cells in the TME (Fig. 5c).