CHAC1 and heart failure: Glutathione metabolism is also involved in endoplasmic reticulum stress and oxidative stress, and 5-oxoproline, the final product of Chac1 enzyme involved in metabolism, is also an important factor leading to heart failure35.In addition, in recent years, studies have found that ferroptosis is also associated with the occurrence of heart failure, which is related to the excessive production of ROS and the inhibition of glutathione synthesis by GPX436.